Degrees
2011, Nottingham Trent University, United Kingdom, PhD, Tumour Biology
2006, Nottingham Trent University, United Kingdom, BSc (Hons), Biomedical Science
Certifications
2018, Leuka, United Kingdom, John Goldman Fellowship for Future Science
International workshop for CLL (IwCLL), Scholarship 2017; 2019
European Hematology Association, Netherlands, Travel Award 2014
Institute of Biomedical Science, United Kingdom, President's Prize
Journal article
Montoya S, Bourcier J, Noviski M, Lu H, Thompson MC, Chirino A, Jahn J, Sondhi AK, Gajewski S, Tan YS, Yung S, Urban A, Wang E, Han C, Mi X, Kim WJ, Sievers Q, Auger P, Bousquet H, Brathaban N, Bravo B, Gessner M, Guiducci C, Iuliano JN, Kane T, Mukerji R, Reddy PJ, Powers J, Rios MSGDL, Ye J, Risso CB, Tsai D, Pardo G, Notti RQ, Pardo A, Affer M, Nawaratne V, Totiger TM, Pena-Velasquez C, Rhodes JM, Zelenetz AD, Alencar A, Roeker LE, Mehta S, Garippa R, Linley A, Soni RK, Skånland SS, Brown RJ, Mato AR, Hansen GM, Abdel-Wahab O, Taylor J. 2024. Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127 Science, 383 :eadi5798 DOI Author Url Publisher Url
Montoya S, Bourcier J, Thompson MC, Noviski M, Tan M, Wang E, Mi X, Brathaban N, Barrientos Risso C, Tsai D, Ye J, Jahn J, Pardo G, Cabuhat L, Notti R, Pardo A, Affer M, Yung S, Luliano J, Powers J, Robbins DW, Nawaratne V, Totiger TM, Pena-Velasquez C, Rhodes JM, Zelenetz AD, Roeker LE, Lu H, Linley A, Mato AR, Abdel-Wahab O, Taylor J. 2022. Kinase Dead BTK Mutations Confer Resistance to Covalent and Noncovalent BTK Inhibitors but Are Susceptible to Clinical Stage BTK Degraders Blood, 140 :1811-1813 DOI Publisher Url
Arthur R, Wathen A, Lemm EA, Stevenson FK, Forconi F, Linley AJ, Steele AJ, Packham G, Valle-Argos B. 2022. BTK-independent regulation of calcium signalling downstream of the B-cell receptor in malignant B-cells. Cellular Signalling, 96 DOI Author Url Publisher Url Public Url
Linley AJ, Karydis LI, Mondru AK, D'Avola A, Al Shmrany H, Cicconi S, Griffin R, Forconi F, Pettitt AR, Kalakonda N, Rawstron AC, Hillmen P, Steele AJ, MacEwan DJ, Packham G, Prior IA, Slupsky JR. 2021. Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells Clinical Cancer Research, 27 :5647-5659 DOI Author Url Publisher Url Public Url
Linley A, Kalakonda N, MacEwan D, Prior I, Slupsky J. 2019. PF370 SIGNAL-OMICS ANALYSIS OF THE IMPACT OF THERAPY ON BCR SIGNALLING IN CHRONIC LYMPHOCYTIC LEUKAEMIA HemaSphere, 3 :136-137 DOI Publisher Url
Maerken M, MacEwan D, Harper N, Slupsky JR, Linley A. 2018. Gene Editing of BTK in Acute Myeloid Leukaemia Using CRISPR-Cas9 Blood, 132 :3952-3952 DOI Publisher Url
Wilson LJ, Linley A, Hammond DE, Hood FE, Coulson JM, MacEwan DJ, Ross SJ, Slupsky JR, Smith PD, Eyers PA, Prior IA. 2017. New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome. Cancer research, 78 :15-29 DOI Author Url Publisher Url Public Url
Aguilar-Hernandez MM, Blunt MD, Dobson R, Yeomans A, Thirdborough S, Larrayoz M, Smith LD, Linley A, Strefford JC, Davies A, Johnson PMW, Savelyeva N, Cragg MS, Forconi F, Packham G, Stevenson FK, Steele AJ. 2016. IL-4 enhances expression and function of surface IgM in CLL cells BLOOD, 127 :3015-3025 DOI Author Url Publisher Url
Yeomans A, Thirdborough SM, Valle-Argos B, Linley A, Krysov S, Hidalgo MS, Leonard E, Ishfaq M, Wagner SD, Willis AE, Steele AJ, Stevenson FK, Forconi F, Coldwell MJ, Packham G. 2016. Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation BLOOD, 127 :449-457 DOI Author Url Publisher Url
Linley A, Krysov S, Ponzoni M, Johnson PW, Packham G, Stevenson FK. 2015. Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells BLOOD, 126 :1902-1910 DOI Author Url Publisher Url
Linley A, Valle-Argos B, Steele AJ, Stevenson FK, Forconi F, Packham G. 2015. Higher levels of reactive oxygen species are associated with anergy in chronic lymphocytic leukemia HAEMATOLOGICA, 100 :E265-E268 DOI Author Url Publisher Url
Linley AJ, Valle-Argos B, Steele AJ, Stevenson FK, Forconi F, Packham G. 2014. Increased Reactive Oxygen Species and the B-Cell Receptor in Chronic Lymphocytic Leukemia Signaling Blood, 124 :3291-3291 DOI Publisher Url
Krysov S, Steele AJ, Coelho V, Linley A, Hidalgo MS, Carter M, Potter KN, Kennedy B, Duncombe AS, Ashton-Key M, Forconi F, Stevenson FK, Packham G. 2014. Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK BLOOD, 124 :3101-3109 DOI Author Url Publisher Url
Linley AJ, Mathieu MG, Miles AK, Rees RC, McArdle SEB, Regad T. 2012. The Helicase HAGE Expressed by Malignant Melanoma-Initiating Cells Is Required for Tumor Cell Proliferation in Vivo JOURNAL OF BIOLOGICAL CHEMISTRY, 287 :13633-13643 DOI Author Url Publisher Url
Linley AJ, Ahmad M, Rees RC. 2011. Tumour-associated antigens: considerations for their use in tumour immunotherapy INTERNATIONAL JOURNAL OF HEMATOLOGY, 93 :263-273 DOI Author Url Publisher Url
Mathieu MG, Linley AJ, Reeder SP, Badoual C, Tartour E, Rees RC, McArdle SEB. 2010. HAGE, a cancer/testis antigen expressed at the protein level in a variety of cancers. Cancer immunity, 10 :2 Author Url
Wang E, Mi X, Thompson MC, Montoya S, Notti RQ, Afaghani J, Durham BH, Penson A, Witkowski MT, Lu SX, Bourcier J, Hogg SJ, Erickson C, Cui D, Cho H, Singer M, Totiger TM, Chaudhry S, Geyer M, Alencar A, Linley AJ, Palomba ML, Coombs CC, Park JH, Zelenetz A, Roeker L, Rosendahl M, Tsai DE, Ebata K, Brandhuber B, Hyman DM, Aifantis I, Mato A, Taylor J, Abdel-Wahab O. Mechanisms of Resistance to Noncovalent Bruton's Tyrosine Kinase Inhibitors The New England journal of medicine, 386 :735-743 DOI Author Url Publisher Url Public Url
Editorial/letter to the editor
Linley AJ, Slupsky JR. 2021. Poor prognosis is ZAP70'ed into focus in CLL Blood, 137 :3586-3587 DOI Author Url Publisher Url