Image of Dr Stefan Roesner

Dr Stefan Roesner

Pharmacy and Biomolecular Sciences

Faculty of Science

Synthesis of functionalised heterocycles, Continuous-flow synthesis, Metal-catalysed cross-coupling reactions, Peptidomimetics

Languages

English
German
Swedish

Degrees

2014, University of Bristol, United Kingdom, PhD, Organic Chemistry
2010, Philipp University of Marburg, Germany, Diploma (MChem), Chemistry

Certifications

2021, University of Warwick, United Kingdom, Postgraduate award in Technology Enhanced Learning

Academic appointments

Senior Lecturer in Organic Chemistry, School of Pharmacy and Biomolecular Science, Liverpool John Moores University, 2024 - present
Assistant Professor, Department of Chemistry, University of Warwick, 2021 - 2024
Senior Research Fellow, Department of Chemistry, University of Warwick, 2016 - 2021
Postdoctoral Research Associate, Department of Chemistry, Massachusetts Institute of Technology, 2015 - 2016

Journal article

Nutter M, Stone H, Shipman M, Roesner S. 2024. Stereoselective synthesis of (R)- and (S)-1,2-diazetidine-3-carboxylic acid derivatives for peptidomimetics Organic & Biomolecular Chemistry, 22 :2974-2977 DOI Author Url Publisher Url Public Url

Saunders GJ, Spring SA, Jayawant E, Wilkening I, Roesner S, Clarkson GJ, Dixon AM, Notman R, Shipman M. 2024. Synthesis and Functionalization of Azetidine-Containing Small Macrocyclic Peptides Chemistry - A European Journal, :1-7 DOI Author Url Publisher Url Public Url

Kim J, Ren X, Zhang Y, Fazzi D, Manikandan S, Andreasen JW, Sun X, Ursel S, Un HI, Peralta S, Xiao M, Town J, Marathianos A, Roesner S, Bui TT, Ludwigs S, Sirringhaus H, Wang S. 2023. Efficient N-Type Organic Electrochemical Transistors and Field-Effect Transistors Based on PNDI-Copolymers Bearing Fluorinated Selenophene-Vinylene-Selenophenes Advanced Science, 10 :1-12 DOI Author Url Publisher Url Public Url

Clarkson GJ, Roesner S. 2022. Synthesis of Benzofuropyridines and Dibenzofurans by a Metalation/Negishi Cross-Coupling/SNAr Reaction Sequence The Journal of Organic Chemistry, 88 :684-689 DOI Author Url Publisher Url Public Url

Sathiyalingam S, Roesner S. 2022. Synthesis of α- and β-Carbolines by a Metalation/Negishi Cross- Coupling/SNAr Reaction Sequence Advanced Synthesis & Catalysis, 364 :1769-1774 DOI Publisher Url Public Url

Dean C, Roesner S, Rajkumar S, Clarkson GJ, Jones M, Shipman M. 2020. Synthesis of sp3-rich chemical libraries based upon 1,2-diazetidines Tetrahedron, 79 :1-5 DOI Publisher Url Public Url

Roesner S, Beadle JD, Tam LKB, Wilkening I, Clarkson GJ, Raubo P, Shipman M. 2020. Development of oxetane modified building blocks for peptide synthesis Organic and Biomolecular Chemistry, 18 :5400-5405 DOI Author Url Publisher Url Public Url

Dean C, Rajkumar S, Roesner S, Carson N, Clarkson GJ, Wills M, Jones M, Shipman M. 2020. Readily accessible sp3-rich cyclic hydrazine frameworks exploiting nitrogen fluxionality Chemical Science, 11 :1636-1642 DOI Author Url Publisher Url Public Url

Roesner S, Saunders GJ, Wilkening I, Jayawant E, Geden JV, Kerby P, Dixon AM, Notman R, Shipman M. 2019. Macrocyclisation of small peptides enabled by oxetane incorporation Chemical Science, 10 :2465-2472 DOI Author Url Publisher Url Public Url

Noble A, Roesner S, Aggarwal VK. 2016. Short Enantioselective Total Synthesis of Tatanan A and 3-epi-Tatanan A Using Assembly-Line Synthesis Angewandte Chemie - International Edition, 55 :15920-15924 DOI Author Url Publisher Url Public Url

Roesner S, Buchwald SL. 2016. Continuous-Flow Synthesis of Biaryls by Negishi Cross-Coupling of Fluoro- and Trifluoromethyl-Substituted (Hetero)arenes Angewandte Chemie - International Edition, 55 :10463-10467 DOI Author Url Publisher Url Public Url

Roesner S, Blair DJ, Aggarwal VK. 2015. Enantioselective installation of adjacent tertiary benzylic stereocentres using lithiation-borylation-protodeboronation methodology. Application to the synthesis of bifluranol and fluorohexestrol Chemical Science, 6 :3718-3723 DOI Author Url Publisher Url

Roesner S, Brown CA, Mohiti M, Pulis AP, Rasappan R, Blair DJ, Essafi S, Leonori D, Aggarwal VK. 2014. Stereospecific conversion of alcohols into pinacol boronic esters using lithiation-borylation methodology with pinacolborane Chemical Communications, 50 :4053-4055 DOI Author Url Publisher Url

Roesner S, Aggarwal VK. 2012. Enantioselective synthesis of (R)-tolterodine using lithiation/borylation- protodeboronation methodology Canadian Journal of Chemistry, 90 :965-974 DOI Author Url Publisher Url

Roesner S, Aggarwal VK. 2012. Organic chemistry: Reactions at the end of a tether Nature, 487 :48-49 DOI Author Url Publisher Url

Roesner S, Casatejada JM, Elford TG, Sonawane RP, Aggarwal VK. 2011. Enantioselective syntheses of (+)-sertraline and (+)-indatraline using lithiation/borylation-protodeboronation methodology Organic Letters, 13 :5740-5743 DOI Author Url Publisher Url

Hilt G, Roesner S. 2011. Substrate-controlled regioselective cobalt(I)-catalysed 1,4-hydrovinylation reactions Synthesis, :662-668 DOI Publisher Url

Kersten L, Roesner S, Hilt G. 2010. Synthesis and characterization of polycarbonyl compounds via their BF 2-adducts Organic Letters, 12 :4920-4923 DOI Author Url Publisher Url

preprint

Mohanrao R, Pinto CS, Suchenko A, Clarkson GJ, Wills M, Roesner S, Shipman M, Balasubramanian MK. 2024. Single-benzene-based clickable fluorophores for in vitro and in vivo bioimaging American Chemical Society (ACS) DOI Publisher Url

Clarkson GJ, Roesner S. 2022. Synthesis of Benzofuropyridines and Dibenzofurans by a Metalation/Negishi Cross-Coupling/SNAr Reaction Sequence American Chemical Society (ACS) DOI Publisher Url

Sathiyalingam S, Roesner S. 2021. Synthesis of α- and β-Carbolines by a Metalation/Negishi Cross-Coupling/SNAr Reaction Sequence American Chemical Society (ACS) DOI Publisher Url

Roesner S, Sathiyalingam S. 2021. Synthesis of α- and β-Carbolines by a Metalation/Negishi Cross-Coupling/SNAr Reaction Sequence Cambridge University Press (CUP) DOI Publisher Url

Chapters

Boswood S, Roesner S. 2024. Methodologies for the synthesis of β-carbolines Targets in heterocyclic systems 27 :1-22 Italian Chemical Society DOI Publisher Url Public Url

Conference publication

Roesner S. 2018. Macrocyclization of Small Peptides Enabled by Oxetane Incorporation JOURNAL OF PEPTIDE SCIENCE, 24 :S60-S60

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