Dr Chrysanthi Fergani
School of Biological and Environmental Sciences
Faculty of Science
Email: C.Fergani@ljmu.ac.uk
Telephone: 0151 231 2545
ORCID
Languages
Greek, Modern (1453-)
English
Degrees
2011, University of Liverpool, United Kingdom, PhD
2008, University of Liverpool, United Kingdom, MSc
2006, University of Thessaly, Greece, DVM
Academic appointments
Lecturer in Mammalian Physiology, Natural Sciences and Psychology, Liverpool John Moore's University, 2018 - present
Postgraduate training
Postdoctoral Fellow, United States, Harvard Medical School, 2015 - 2018
Instructor in Medicine, United States, University of Mississippi Medical Center, 2012 - 2015
Postdoctoral Fellow, United States, University of Michigan, 2011 - 2012
Highlighted publications
León S, Fergani C, Talbi R, Maguire CA, Gerutshang A, Seminara SB, Navarro VM. 2020. Tachykinin signaling is required for the induction of the preovulatory LH surge and normal LH pulses. Neuroendocrinology, DOI Author Url Publisher Url Public Url
León S, Fergani C, Talbi R, Simavli S, Maguire CA, Gerutshang A, Navarro VM. 2019. Characterization of the Role of NKA in the Control of Puberty Onset and Gonadotropin Release in the Female Mouse Endocrinology, 160 :2453-2463 DOI Author Url Publisher Url Public Url
Lippincott MF, León S, Chan Y-M, Fergani C, Talbi R, Farooqi IS, Jones CM, Arlt W, Stewart SE, Cole TR, Terasawa E, Hall JE, Shaw ND, Navarro VM, Seminara SB. 2019. Hypothalamic Reproductive Endocrine Pulse Generator Activity Independent of Neurokinin B and Dynorphin Signaling. Journal of Clinical Endocrinology & Metabolism, 104 :4304-4318 DOI Author Url Publisher Url Public Url
Fergani C, Leon S, Padilla SL, Verstegen AMJ, Palmiter RD, Navarro VM. 2018. NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice eLife, 7 DOI Author Url Publisher Url Public Url
Ross RA, Leon S, Madara JC, Schafer D, Fergani C, Maguire CA, Verstegen AM, Brengle E, Kong D, Herbison AE, Kaiser UB, Lowell BB, Navarro VM. 2018. PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse. eLife, 7 DOI Author Url Publisher Url Public Url
Fergani C, Mazzella L, Coolen LM, McCosh RB, Hardy SL, Newcomb N, Grachev P, Lehman MN, Goodman RL. 2016. Do Substance P and Neurokinin A Play Important Roles in the Control of LH Secretion in Ewes? Endocrinology, 157 :4829-4841 DOI Author Url Publisher Url Public Url
Fergani C, Routly JE, Jones DN, Pickavance LC, Smith RF, Dobson H. 2014. Activation of Cells Containing Estrogen Receptor Alpha or Somatostatin in the Medial Preoptic Area, Arcuate Nucleus, and Ventromedial Nucleus of Intact Ewes During the Follicular Phase, and Alteration after Lipopolysaccharide Biology of Reproduction, 91 :1-12 DOI Author Url Publisher Url Public Url
Sheldon IM, Cronin JG, Healey GD, Gabler C, Heuwieser W, Streyl D, Bromfield JJ, Miyamoto A, Fergani C, Dobson H. 2014. Innate immunity and inflammation of the bovine female reproductive tract in health and disease REPRODUCTION, 148 :R41-R51 DOI Author Url Publisher Url
Journal article
Leon S, Talbi R, McCarthy EA, Ferrari K, Fergani C, Naule L, Choi JH, Carroll RS, Kaiser UB, Aylwin CF, Lomniczi A, Navarro VM. 2021. Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2. eLife, 10 DOI Author Url Publisher Url Public Url
Lindo AN, Thorson JF, Bedenbaugh MN, McCosh RB, Lopez JA, Young SA, Meadows LJ, Bowdridge EC, Fergani C, Freking BA, Lehman MN, Hileman SM, Lents CA. 2021. Localization of kisspeptin, NKB, and NK3R in the hypothalamus of gilts treated with the progestin altrenogest Biology of Reproduction, DOI Author Url Publisher Url Public Url
León S, Fergani C, Talbi R, Maguire CA, Gerutshang A, Seminara SB, Navarro VM. 2020. Tachykinin signaling is required for the induction of the preovulatory LH surge and normal LH pulses. Neuroendocrinology, DOI Author Url Publisher Url Public Url
León S, Fergani C, Talbi R, Simavli S, Maguire CA, Gerutshang A, Navarro VM. 2019. Characterization of the Role of NKA in the Control of Puberty Onset and Gonadotropin Release in the Female Mouse Endocrinology, 160 :2453-2463 DOI Author Url Publisher Url Public Url
Lippincott MF, León S, Chan Y-M, Fergani C, Talbi R, Farooqi IS, Jones CM, Arlt W, Stewart SE, Cole TR, Terasawa E, Hall JE, Shaw ND, Navarro VM, Seminara SB. 2019. Hypothalamic Reproductive Endocrine Pulse Generator Activity Independent of Neurokinin B and Dynorphin Signaling. Journal of Clinical Endocrinology & Metabolism, 104 :4304-4318 DOI Author Url Publisher Url Public Url
Leon S, Fergani C, Talbi R, Serap S, Maguire C, Gerutshang A, Seminara S, Navarro V. 2019. SAT-LB070 Tachykinins Are Essential for the Induction of the Preovulatory LH Surge in Mice Journal of the Endocrine Society, 3 DOI Publisher Url
Fergani C, Leon S, McCarthy E, Navarro V. 2019. SAT-425 NKB Signaling in the Posterodorsal Medial Amygdala Stimulates Gonadotropin Release in a Kisspeptin-Independent Manner in Female Mice Journal of the Endocrine Society, 3 DOI Publisher Url
Fergani C, McCarthy E, Leon S, Navarro V. 2019. SAT-405 Activation of Kiss1 Neurons in the Posterodorsal Medial Amygdala Stimulates Gonadotropin Release via the Release of Kisspeptin in Female Mice Journal of the Endocrine Society, 3 DOI Publisher Url
Fergani C, Leon S, Padilla SL, Verstegen AMJ, Palmiter RD, Navarro VM. 2018. NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice eLife, 7 DOI Author Url Publisher Url Public Url
Ross RA, Leon S, Madara JC, Schafer D, Fergani C, Maguire CA, Verstegen AM, Brengle E, Kong D, Herbison AE, Kaiser UB, Lowell BB, Navarro VM. 2018. PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse. eLife, 7 DOI Author Url Publisher Url Public Url
Fergani C, Routly JE, Jones DN, Pickavance LC, Smith RF, Dobson H. 2017. KNDy neurone activation prior to the LH surge of the ewe is disrupted by LPS Reproduction, 154 :281-292 DOI Author Url Publisher Url Public Url
Fergani C, Navarro VM. 2017. Expanding the role of tachykinins in the neuroendocrine control of reproduction Reproduction, 153 :R1-R14 DOI Author Url Publisher Url Public Url
Fergani C, Mazzella L, Coolen LM, McCosh RB, Hardy SL, Newcomb N, Grachev P, Lehman MN, Goodman RL. 2016. Do Substance P and Neurokinin A Play Important Roles in the Control of LH Secretion in Ewes? Endocrinology, 157 :4829-4841 DOI Author Url Publisher Url Public Url
Ahn T, Fergani C, Coolen LM, Padmanabhan V, Lehman MN. 2015. Prenatal Testosterone Excess Decreases Neurokinin 3 Receptor Immunoreactivity within the Arcuate Nucleus KNDy Cell Population Journal of Neuroendocrinology, 27 :100-110 DOI Author Url Publisher Url Public Url
Fergani C, Routly JE, Jones DN, Pickavance LC, Smith RF, Dobson H. 2015. Co-Expression of c-Fos with Oestradiol Receptor alpha or Somatostatin in the Arcuate Nucleus, Ventromedial Nucleus and Medial Preoptic Area in the Follicular Phase of Intact Ewes: Alteration after Insulin-Induced Hypoglycaemia Reproduction in Domestic Animals, 50 :68-75 DOI Author Url Publisher Url Public Url
Fergani C, Routly JE, Jones DN, Pickavance LC, Smith RF, Dobson H. 2014. Activation of Cells Containing Estrogen Receptor Alpha or Somatostatin in the Medial Preoptic Area, Arcuate Nucleus, and Ventromedial Nucleus of Intact Ewes During the Follicular Phase, and Alteration after Lipopolysaccharide Biology of Reproduction, 91 :1-12 DOI Author Url Publisher Url Public Url
Sheldon IM, Cronin JG, Healey GD, Gabler C, Heuwieser W, Streyl D, Bromfield JJ, Miyamoto A, Fergani C, Dobson H. 2014. Innate immunity and inflammation of the bovine female reproductive tract in health and disease REPRODUCTION, 148 :R41-R51 DOI Author Url Publisher Url
Sliwowska JH, Fergani C, Gawalek M, Skowronska B, Fichna P, Lehman MN. 2014. Insulin: Its role in the central control of reproduction Physiology and Behavior, 133 :197-206 DOI Author Url Publisher Url Public Url
Fergani C, Routly JE, Jones DN, Pickavance LC, Smith RF, Dobson H. 2014. Kisspeptin, c-Fos and CRFR Type 2 Co-expression in the Hypothalamus after Insulin-Induced Hypoglycaemia REPRODUCTION IN DOMESTIC ANIMALS, 49 :433-440 DOI Author Url Publisher Url
Fergani C, Routly JE, Jones DN, Pickavance LC, Smith RF, Dobson H. 2013. Kisspeptin, c-Fos and CRFR type 2 expression in the preoptic area and mediobasal hypothalamus during the follicular phase of intact ewes, and alteration after LPS Physiology and Behavior, 110 :158-168 DOI Author Url Publisher Url Public Url
Dobson H, Fergani C, Routly JE, Smith RF. 2012. Effects of stress on reproduction in ewes ANIMAL REPRODUCTION SCIENCE, 130 :135-140 DOI Author Url Publisher Url
Fergani C, Saifullizam AK, Routly JE, Smith RF, Dobson H. 2012. Estrous behavior, luteinizing hormone and estradiol profiles of intact ewes treated with insulin or endotoxin PHYSIOLOGY & BEHAVIOR, 105 :757-765 DOI Author Url Publisher Url
preprint
León S, Fergani C, Talbi R, Simavli S, Maguire CA, Gerutshang A, Seminara SB, Navarro VM. 2018. Redundancy in the central tachykinin systems safeguards puberty onset and fertility Cold Spring Harbor Laboratory DOI Publisher Url
Fergani C, León S, Padilla SL, Verstegen AMJ, Palmiter RD, Navarro VM. 2018. NKB Signaling in the Medial Amygdala Stimulates Gonadotropin Release in a Kisspeptin-Independent Manner in Female Mice Cold Spring Harbor Laboratory DOI Publisher Url
Ross RA, León S, Madara JC, Schafer D, Fergani C, Maguire CA, Verstegen AMJ, Brengle E, Kong D, Herbison AE, Kaiser UB, Lowell BB, Navarro VM. 2018. PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse Cold Spring Harbor Laboratory DOI Publisher Url
Conference publication
Fergani C, Routly J, Jones D, Pickavance L, Smith R, Dobson H. 2011. c-Fos and kisspeptin immunoreactivity in the hypothalamus of intact ewes treated with insulin or endotoxin REPRODUCTION IN DOMESTIC ANIMALS, 15th Annual Conference of the European-Society-for-Domestic-Animal-Reproduction (ESDAR) 46 :75-75 Author Url
Fergani C, Saifullizam AK, Routly JE, Smith RF, Dobson H. 2010. Oestrous behaviour and luteinising hormone profiles of intact ewes treated with insulin or endotoxin REPRODUCTION IN DOMESTIC ANIMALS, 14th Annual Conference of theEuropean-Societies-Domestic-Animals-Reproduction/22nd Annual Meeting of the EU-AI-Vets 45 :59-59 Author Url
Fergani C, Kadir S, Routly JE, Jones DN, Smith RF, Dobson H. Endocrine and behaviour profiles of intact ewes treated with endotoxin. British Society for Neuroendocrinology (BSN) Conference
Fergani C, Routly JE, Pickavance LC, Smith RF, Dobson H. Activation of estrogen receptor α-containing cells in the medial preoptic area, arcuate nucleus and ventromedial nucleus of intact ewes during the follicular phase and its alteration after endotoxin . 94th Endocrine Society meeting
Fergani C, Routly JE, Lehman MN, Pickavance LC, Smith RF, Dobson H. Activation of KNDY cells in the arcuate nucleus of the hypothalamus of intact ewes during the follicular phase and its alteration after endotoxin Society for Neuroscience Conference
Fergani C, Padmanabhan V, Coolen LM, Lehman MN. Prenatal Bisphenol A treatment reduces kisspeptin cell number in the POA and causes an imbalance of KNDy peptides in the ARC during adult life in sheep The 95th Endocrine Society’s meeting
Hileman SM, Measows LJ, Porter KL, Coolen LM, Fergani C, Rempel LA, Cushman RA, Miles JR, Lents CA. Effect of progesterone on kisspeptin and neurokinin B cell numbers in the arcuate nucleus of the female pig Society for Neuroscience Meeting
Fergani C, Padmanabhan V, Coolen LM, Lehman MN. Prenatal testosterone alters KNDy cell expression in the arcuate nucleus of pre-pubertal ten week old male and female lambs Society for Neuroscience Meeting
Fergani C, Intapad S, Rollins S, Lehman MN, Alexander BT, Coolen LM. Early onset of reproductive senescence programmed by intrauterine growth restriction in the female rat is accompanied by altered KNDy cell peptide expression and hypertrophy in the arcuate nucleus of the hypothalamus Society for Neuroscience Meeting
Fergani C, Leon S, Navarro VM. Tachykinins Can Stimulate LH Release Via a Kisspeptin-Independent Mechanism in the Presence of Estrogen The 99th Endocrine Society’s meeting
Leon S, Fergani C, Simavli S, Maguire CA, Seminara S, Navarro VM. Neurokinin A advances puberty onset and interacts with neurokinin B (and SP) in the control of GnRH release in the female mouse 100th Endocrine Society meeting
Fergani C, Leon S, Navarro VM. Activation of NKB/NK3R Signaling in the Amygdala Stimulates Gonadotropin Release in a Kisspeptin-Independent but Estradiol-Dependent Manner
Leon S, Fergani C, Talbi R, Serap S, Maguire C, Gerutshang A, Seminara S, Navarro V. Tachykinins Are Essential for the Induction of the Preovulatory LH Surge in Mice
Fergani C, McCarthy E, Leon S, Navarro V. Activation of Kiss1 Neurons in the Posterodorsal Medial Amygdala Stimulates Gonadotropin Release via the Release of Kisspeptin in Female Mice
Fergani C, Leon S, McCarthy E, Navarro V. NKB Signaling in the Posterodorsal Medial Amygdala Stimulates Gonadotropin Release in a Kisspeptin-Independent Manner in Female Mice